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In approximately 50-60% of cases, development of the secondary T790M mutation in EGFR is responsible for TKI therapy resistance. However,
These T790M mutations arrive either innately, or upon treatment with a TKI as a resistance mutation [15]. The T790M mutation
de TS Mok · 2017 · Citat de 3063 ori — In this randomized, international, open-label, phase 3 trial, we
de PS Wu · 2024 — Secondary mutation, T790M, conferring tyrosine kinase inhibitors (TKIs) resistance beyond oncogenic epidermal growth factor
25 aug. 2024 — The novel targeted therapy abivertinib showed efficacy in a clinical trial of patients with EGFR T790M
generation EGFR TKIs. Owing to its biologic relevance in the response
acum 5 zile — Lazertinib is an oral, third-generation, brain-penetrant EGFR TKI that targets both the T790M mutation and activating
ctDNA testing provides a rapid, minimally invasive blood testing alternative to traditional biopsy or resection tissue analysis of EGFR T790M
T790M mutation occurs about 50% of the 1st and 2nd generation TKI resistance. To be more specific, 790 position of
de K Hirano · 2020 · Citat de 1 ori — configuration of C797S and T790M. Key words： EGFR gene